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We surveyed specific cardiovascular cell types and found that the effect of GLP-1(2836) on intracellular cAMP levels in both atrial and ventricular CMs was no different than that of the scrambled control (Supplemental Figure 4A)

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Metabolic state-driven approach is an efficient strategy for identifying metabolic imbalances and nutrient metabolites that have potential as metabolic reprogramming agents 10

This nomenclature shift aims to better reflect the underlying metabolic etiology, reduce stigmatization, and improve consistency in clinical trial enrollment